| 主权项 |
1. A compound of formula (II): or a pharmaceutically acceptable salt thereof, wherein: R1 is H; R2 is H, aralkyl, or heterocyclyl; m and n are independently an integer from 0 to 1; x is an integer from 0 to 4; y is an integer from 0 to 3; A is a cycloalkyl, heterocycloalkyl, aromatic, or heteroaromatic ring containing ring moieties Q1, Q2, Q3, and Q4, which are taken together with the carbon atoms at positions a and a′ to form ring A; B is a cycloalkyl, heterocycloalkyl, aromatic, or heteroaromatic ring containing ring moieties Q5, Q6, Q7, and Q8, which are taken together with the carbon atoms at positions a and a′ to form ring B; Q1, Q2, Q3, Q4, Q5, Q6, Q7, and Q8 are independently selected from the group consisting of C, CH, CH2, N, NR10, O, and S, provided that: (1) when rings A and B together form naphthalene, x is an integer from 1 to 3 or y is the integer 2 or 3 and R8 is other than Cl, or (2) at least one of Q1, Q2, Q3, Q4, Q5, Q6, Q7, and Q8 is N, NR10, O, or S, or (3) when rings A and B together form benzofuran, ring A is the oxygen containing ring and ring B is phenyl, or (4) when one of rings A and B is phenyl and for the other of rings A and B at least one of Q1, Q2, Q3, and Q4 is N or NR10, then ring B is phenyl; each R8 and R9 is independently selected from halo, alkylsulfonyl, N-hydroxylsulfonamidyl, perhaloalkyl, nitro, aryl, cyano, alkoxy, perhaloalkoxy, alkyl, substituted aryloxy, alkyl sulfanyl, alkyl sulfinyl, heterocycloalkyl, substituted heterocycloalkyl, NH2, OH, C(O)OH, C(O)Oalkyl, NHC(O)alkylC(O)OH, C(O)NH2, NHC(O)alkylC(O)alkyl, NHC(O)alkenylC(O)OH, NHC(O)NH2, OalkylC(O)Oalkyl, NHC(O)alkyl, C(═N—OH)NH2, cycloalkoxy, cycloalkylsulfanyl, arylsulfanyl, and arylsulfinyl; and R10 is H, alkyl, acyl, or sulfonyl. |
