发明名称 PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING AND USES THEREOF
摘要 The invention relates to the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia using a SGLT-2 inhibitor. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.
申请公布号 US2017020907(A1) 申请公布日期 2017.01.26
申请号 US201615286017 申请日期 2016.10.05
申请人 Boehringer Ingelheim International GmbH 发明人 EICKELMANN Peter;MARK Michael;SEMAN Leo John;THOMAS Leo;BROEDL Uli Christian;GREMPLER Rolf
分类号 A61K31/7034;A61K31/7048 主分类号 A61K31/7034
代理机构 代理人
主权项 1. Method for preventing, slowing the progression of, delaying or treating a metabolic disorder selected from the group consisting of type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance, impaired fasting blood glucose, hyperglycemia, postprandial hyperglycemia, overweight, obesity, metabolic syndrome, gestational diabetes, new onset diabetes after transplantation (NODAT) and complications associated therewith, and post-transplant metabolic syndrome (PTMS) and complications associated therewith in a patient in need thereof characterized in that a pharmaceutical composition comprising an SGLT2 inhibitor is administered to the patient, wherein the SGLT2 inhibitor is a glucopyranosyl-substituted benzene derivative of the formula (I) wherein R1 denotes Cl, methyl or cyano; R2 denotes H, methyl, methoxy or hydroxy and R3 denotes ethyl, cyclopropyl, ethynyl, ethoxy, (R)-tetrahydrofuran-3-yloxy or (S)-tetrahydrofuran-3-yloxy; or a prodrug thereof.
地址 Ingelheim am Rhein DE
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