| 摘要 |
A formulation for use in treating a condition, wherein the formulation comprises a compound that activates endothelial-specific receptor tyrosine kinase 2 (Tie-2) or a pharmaceutically-acceptable salt thereof, and an agent that increases aqueous solubility of the compound that activates Tie-2 or the pharmaceutically-acceptable salt thereof as compared to aqueous solubility of the compound that activates Tie-2, or the pharmaceutically acceptable salt thereof in absence of the agent. Preferably, the compounds that are effective for activation of Tie-2 are certain sulfamic acid compounds having human protein tyrosine phosphatase-beta (HPTP-β) inhibitory activity. The compounds can provide effective therapy for conditions associated with angiogenesis, for example, ocular conditions. Preferably, the agent that increases aqueous solubility of the compound is an alcohol, more preferably benzyl alcohol. Preferred ocular conditions to be treated include diabetic macular oedema, diabetic retinopathy, age-related macular degeneration and vascular leak. |
