| 发明名称 | Kinase modulation and indications therefor | ||
| 摘要 | Compounds, compositions and methods useful for treatment of Flt3-mediated diseases or conditions are provided herewith. Also provided herewith are methods for modulating the receptor protein tyrosine like kinase 3(Flt3). | ||
| 申请公布号 | US9550768(B2) | 申请公布日期 | 2017.01.24 |
| 申请号 | US201313793881 | 申请日期 | 2013.03.11 |
| 申请人 | Plexxikon Inc. | 发明人 | Zhang Chao;Bollag Gideon;Habets Gaston;Zhang Jiazhong;Ibrahim Prabha N.;Wu Guoxian |
| 分类号 | A61K31/4439;C07D471/04;A61K45/06;A61K31/444;A61K31/506;A61K31/5377 | 主分类号 | A61K31/4439 |
| 代理机构 | Sheppard Mullin Richter & Hampton LLP | 代理人 | Sheppard Mullin Richter & Hampton LLP |
| 主权项 | 1. A method for treating a subject suffering from acute myeloid leukemia (AML), said method comprising administering to the subject an effective amount of a compound having the formula: or a pharmaceutically acceptable salt, tautomer or isomer thereof, wherein the subject has an FMS-like tyrosine kinase (Flt3) gene with an internal tandem duplication (ITD) mutation. | ||
| 地址 | Berkeley CA US | ||