Batch authoring tool and bioreactor control system

摘要

A bioreactor control system comprises a batch server for controlling a bioreactor system in response to a recipe, a batch software system for generating a control sequence for the bioreactor system via the batch server for implementing the recipe, and a recipe conversion system that inputs the recipe into the batch software system. Preferably, the recipe conversion system reads a word processor file containing the recipe and interprets styles applied to text in the word processor file as indicating equipment and phases of the recipe to the recipe conversion system. Generally, the bioreactor system includes one or more bioreactors and additional hardware to perform the upstream and downstream processing. The document properties of the word processor file containing the recipe are applied as header information for the recipe input into the batch software system. This system solves a problem associated with traditional batching software systems, in which the authoring of recipes on the systems can be relatively arcane. Here, the recipe can be authored on a common word processor.

主权项

1. A bioreactor control system comprising:
a bioreactor system including a bioreactor connected to at least one upstream processing module and to at least one downstream processing module, the upstream and downstream processing modules each including at least one of a harvest/clarification module, a chromatography module, an ultrafiltration/diafiltration (UF/DF) module, a buffer and media preparation module, and a module for preparation of an inoculums; a batch server that includes a batch software system that generates a control sequence based at least in part on a recipe, the control sequence configured to adapt the batch server to control the bioreactor system; a recipe authoring system for generating the recipe; a recipe conversion system that includes at least one processor configured to:
read in a word processor file having a plurality of paragraphs that include instructions defining the recipe, at least one of the paragraphs having one or more applied custom paragraph styles;parse the word processor file by iterating through the plurality of paragraphs and identifying the one or more applied custom paragraph styles;generate the control sequence based at least in part on the instructions and the identified one or more applied custom paragraph styles; andwherein the one or more applied custom paragraph styles indicate at least one of a piece of equipment and at least one of an operational phase of the bioreactor system to be controlled by the batch server.