| 发明名称 | Riboregulator compositions and methods of use | ||
| 摘要 | The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use for detecting RNAs in a sample such as a well and in modulating protein synthesis and expression. | ||
| 申请公布号 | US9550987(B2) | 申请公布日期 | 2017.01.24 |
| 申请号 | US201314440917 | 申请日期 | 2013.11.06 |
| 申请人 | President and Fellows of Harvard College;Trustees of Boston University | 发明人 | Green Alexander A.;Yin Peng;Collins James J. |
| 分类号 | C07H21/02;C07H21/04;C12N15/85;C12N15/11;C12N15/113;C12N15/115;C12N15/67;C12Q1/68 | 主分类号 | C07H21/02 |
| 代理机构 | Wolf, Greenfield & Sacks, P.C. | 代理人 | Wolf, Greenfield & Sacks, P.C. |
| 主权项 | 1. A toehold riboregulator comprising an RNA comprising in a 5′ to 3′ order (1) a single-stranded toehold domain,(2) a fully or partially double-stranded stem domain comprising (i) an initiation codon, and(ii) a loop domain comprising a ribosome binding site, and(3) a coding domain. | ||
| 地址 | Cambridge MA US | ||