发明名称 |
Chimeric fibroblast growth factor 23/fibroblast growth factor 19 proteins and methods of use |
摘要 |
The present invention relates to an isolated chimeric protein. The isolated chimeric protein includes an N-terminus coupled to a C-terminus, where the N-terminus includes an N-terminal portion from a fibroblast growth factor (“FGF”) 23 molecule and the C-terminus includes a C-terminal portion from an FGF19 molecule. The present invention also relates to a pharmaceutical composition including an isolated chimeric protein and a pharmaceutically acceptable carrier. The isolated chimeric protein includes an N-terminus coupled to a C-terminus, where the N-terminus includes an N-terminal portion from a fibroblast growth factor (“FGF”) 23 molecule and the C-terminus includes a C-terminal portion from an FGF19 molecule, and a pharmaceutically-acceptable carrier. Yet another aspect of the present invention relates to a method for treating a subject suffering from a disorder. This method includes selecting a subject suffering from the disorder and administering to the subject a therapeutically effective amount of a chimeric protein according to the present invention. |
申请公布号 |
US9550820(B2) |
申请公布日期 |
2017.01.24 |
申请号 |
US201414185366 |
申请日期 |
2014.02.20 |
申请人 |
New York University |
发明人 |
Mohammadi Moosa;Goetz Regina |
分类号 |
A61K38/18;C07K14/50;A61K45/06;A61K38/00 |
主分类号 |
A61K38/18 |
代理机构 |
LeClairRyan, a Professional Corporation |
代理人 |
LeClairRyan, a Professional Corporation |
主权项 |
1. An isolated chimeric protein comprising:
an N-terminus coupled to a C-terminus, wherein the N-terminus comprises an N-terminal portion from an FGF23 molecule and the C-terminus comprises a C-terminal portion from an FGF19 molecule, wherein the isolated chimeric protein has the amino acid sequence of SEQ ID NO: 254. |
地址 |
New York NY US |