Polymers from stabilized imines

摘要

The disclosure describes new compositions and methods related to polyaminals and related polymers. The compositions are useful as therapeutic/drug conjugates, self-healing materials, reversible crosslinking materials, degradable hydrogels, protective coatings, and as metal scavenging agents. New atom efficient synthetic schemes are disclosed, which yield previously unobtainable high molecular weight polyaminals.

主权项

1. A polymer having the general structure wherein R′ is an organic group, a hetero-organic group, or a hetero-atom; each X is an organic group, a hetero-organic group, a hetero-atom, or a hydrogen atom; and wherein at least two X groups are each a polyaminal segment —NH—CH2-Nuc-R″-Nuc-CH2—; and wherein Nuc is a nucleophilic atom; and wherein R″ is an organic group or a hetero-organic group.