| 发明名称 | Compositions and methods for modulating myeloid derived suppressor cells | ||
| 摘要 | Provided are methods and compositions for modulating the differentiation of a myeloid derived suppressor cell (MDSC). In particular, described herein are miR-142 polynucleotides and miR-223 polynucleotides that can be used to modulate differentiation of MDSCs. Increased differentiation of a MDSC population, or cells within an MDSC population, can be achieved by increasing the miR-142 and/or miR-223 polynucleotides in a MDSC. | ||
| 申请公布号 | US9550992(B2) | 申请公布日期 | 2017.01.24 |
| 申请号 | US201214361537 | 申请日期 | 2012.12.03 |
| 申请人 | University of South Florida | 发明人 | Mohapatra Shyam S.;Bharadwaj Srinivas Nagaraj;Mohapatra Subhra |
| 分类号 | C12N15/11;C12N15/113;C12Q1/68;C12N5/0789;C12N5/0784;C12N5/0786 | 主分类号 | C12N15/11 |
| 代理机构 | Thomas | Horstemeyer, LLP | 代理人 | Thomas | Horstemeyer, LLP |
| 主权项 | 1. A method of modulating differentiation of a myeloid derived suppressor cell (MDSC) comprising: administering an amount of a miR-142 to the MDSC. | ||
| 地址 | Tampa FL US | ||