发明名称 |
COMPOSITIONS AND METHODS FOR TREATING PERITONEAL CANCERS |
摘要 |
The present disclosure provides compositions and methods for treating a peritoneal cancer in a subject. The methods include administering a T cell which is genetically modified to express a chimeric T cell receptor protein. The chimeric T cell receptor protein may include a T cell receptor signaling domain fused to the tumor associated antigen-binding fragment of an antibody or a T cell receptor signaling domain fused to a naturally occurring ligand which specifically binds to a tumor cell surface protein. The compositions and methods disclosed herein are therapeutically effective to reduce, for example, tumor burden, abdominal ascites, peritoneal mucin, or serum tumor marker levels. |
申请公布号 |
WO2017011670(A1) |
申请公布日期 |
2017.01.19 |
申请号 |
WO2016US42302 |
申请日期 |
2016.07.14 |
申请人 |
PROSPECT CHARTERCARE RWMC, LLC D/B/A ROGER WILLIAMS MEDICAL CENTER |
发明人 |
KATZ, Steven C.;JUNGHANS, Richard |
分类号 |
A61K39/00;A61P35/00;C07K14/725;C07K16/28;C12N5/0783;C12N5/10 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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