| 主权项 |
1. A compound of formula I or a pharmaceutically acceptable salt, tautomer, isotopologue or hydrate thereof, wherein: R1 is optionally substituted C4-C6 carbocyclyl; each R2 and R3 is independently selected from optionally substituted aryl or optionally substituted heteroaryl; R4 is alkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aralkyl, or optionally substituted heteroaralkyl; ring A is 4-6 membered non-aromatic ring having 0-1 additional heteroatoms selected from N, O or S, wherein ring A is optionally substituted with one or two R5 groups; each R5 is independently halo; —CF3; —CN; —OR6; —N(R6)2; —C(O)C1-C4 alkyl; C1-C4 haloalkyl; C1-C4 alkyl optionally substituted with —OR6 or —N(R6)2; —O—C1-C4 alkyl optionally substituted with halo, —OR6 or —N(R6)2; —SO2N(R6)2; —SO2(C1-C4 alkyl); —NR6SO2R6; C3-C5 carbocyclyl optionally substituted with one or two R6 groups; —O—(C3-C6 carbocyclyl optionally substituted with one or two R6 groups); 5-6 membered heteroaryl; —C1-C4 alkyl-C(O)O—C1-C4 alkyl; or —C(O)O—C1-C4 alkyl; or each R6 is independently H or C1-C3 alkyl. |
