Singlet Oxygen-Labile Linkers and Methods of Production and Use Thereof

摘要

Activatable compositions that include at least one functional moiety and at least one cleavable linker directly or indirectly linked to the at least one functional moiety are disclosed. The at least one functional moiety is inactive when linked to the linker and activated upon cleavage of the linker. Methods of production and use of the activatable composition are also disclosed.

主权项

1. An activatable composition, comprising:
at least one functional moiety; at least one singlet oxygen-labile linker selected from the group consisting of aminoacrylate, aminoacrylthioate, and aminoacrylamide, the at least one singlet oxygen-labile linker linked to the at least one functional moiety, wherein the at least one functional moiety is inactive until the at least one singlet oxygen-labile linker is cleaved by singlet oxygen, whereby the at least one functional moiety becomes activated; and a sensitizer, which when exposed to an activator results in generation of singlet oxygen by the sensitizer.