METHODS OF TREATING CANCER

摘要

The present invention provides methods and compositions for treating non-small-cell lung cancer (NSCLC) by administering a) a composition comprising nanoparticles that comprise paclitaxel and an albumin and b) a platinum-based agent (e.g., carboplatin). The present application also provides methods of treating prostate cancer by administering to the individual a) an effective amount of a composition comprising nanoparticles comprising docetaxel and an albumin; and b) an effective amount of a steroid.

主权项

1. A method of treating NSCLC in an individual comprising administering to the individual a) an effective amount of a composition comprising nanoparticles comprising paclitaxel and an albumin and b) an effective amount of a platinum-based agent, wherein treatment is based upon the NSCLC having one or more characteristics selected from the group consisting of (i) differential levels of caveolin-1 (CAV1), (ii) differential levels of SPARC, (iii) differential levels of hypoxia markers, (iv) differential levels of tumor acidity, differential levels of gp60, (vi) differential levels of thymidylate synthase (TS), (vii) differential levels of S phase kinase-associated protein (Skp2), differential loss of heterozygosity (LOH) of single-nucleotide polymorphism (SNP), (ix) differential Kras mutations, differential methylation of promoter region of tumor-related genes, and (xi) differential albumin uptake.