发明名称 |
HUMAN CD3 BINDING ANTIBODY |
摘要 |
The disclosure relates to human CD3 binding antibodies comprising a heavy chain and light chain wherein said heavy chain comprises a variable region that comprises the amino acid sequence: QVQLV QSGGG VVQPG RSLRL SCVAS GFTFS SYGMH WVRQA PGKGL EWVAA IWYX1X2RKQDY ADSVK GRFTI SRDNS KNTLY LQMNS LRAED TAVYY CTRGT GYNWF DPWGQ GTLVT VSS with 0-5 amino acid insertions, deletions, substitutions, additions or a combination thereof The disclosure also relates to with bispecific antibodies that have a heavy chain as defined herein above. Methods of production of the antibody, cells producing the antibody and with (medical) uses of the antibody are provided. |
申请公布号 |
WO2017010874(A1) |
申请公布日期 |
2017.01.19 |
申请号 |
WO2016NL50507 |
申请日期 |
2016.07.08 |
申请人 |
MERUS N.V. |
发明人 |
BAKKER, Alexander Berthold Hendrik;VAN LOO, Pieter Fokko |
分类号 |
C07K16/28;A61K39/00;A61K39/395 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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