Compositions And Methods For Modulating And Redirecting Immune Responses

摘要

Provided herein are methods of modulating and redirecting an immune response. Compositions and methods for killing targeted cells in a cell population are also provided wherein, a cell population containing target cells expressing a target associated antigen and T cells are contacted with 1, 2, or more immune checkpoint antagonists and a multispecific T cell-redirecting agent that specifically binds the target associated antigen expressed on the target cells and specifically binds a T cell surface antigen.

主权项

1. A method of killing target cells in a cell population, comprising contacting a cell population containing target cells expressing a target associated antigen and T cells with (a) 1, 2, or more immune checkpoint antagonists (ImCpAnts) that specifically bind 2 or more different targets of an immune checkpoint pathway and (b) a multispecific T cell-redirecting agent (MsTC-Redir) that (i) specifically binds the target associated antigen expressed on the target cells and (ii) specifically binds a T cell surface antigen, wherein the contacting of the cell population with (a) and (b) leads to death of target cells.