| 摘要 |
Provided are a production method of compound (9) useful as a therapeutic drug for diabetes and a production intermediate therefor. (a) Diester (3) is synthesized by the reaction of compound (1) and compound (2), (b) ester (4) is synthesized by deprotection of diester (3) (or ester (4) is synthesized by the reaction of compound (5) and compound (2)), (c) ester (4) is converted to acid halide, (d) the acid halide is reacted with amidinophenol derivative, and (e) the obtained diester derivative is deprotected under acidic conditions, and converted to compound (9):
wherein R 1 is a halogen atom, R 4 is a lower alkyl group, R 5 is a lower alkyl group, and R 12 is a hydrogen atom or a halogen atom. |
