| 主权项 |
1. A compound of Formula (I)or a pharmaceutically acceptable salt thereof, wherein
L is a bond; A and A′ are wherein “” represents the point of attachment to X and X′ and “” represents the point of attachment to L; and wherein: R2 is selected from hydrogen, alkyl, and halo; and R3 is selected from hydrogen, alkoxy, alkyl, cyano, halo, and haloalkoxy; X and X′ are wherein each group is drawn with the carbon atom being attached to A or A′ and with the nitrogen atom attached to the carbonyl group and wherein: n is 1; s is 0, 1, 2, 3, or 4; Y is selected from CH2,CHR4, and C(R4)2; and each R4 is independently selected from alkoxy, alkyl, aryl, cyano, halo, haloalkoxy, haloalkyl, hydroxy, —NRaRb, and thioalkyl, wherein the alkyl can optionally form a fused three- to six-membered ring or a bridged four-or five-membered ring with another carbon atom on the ring; or can optionally form a spirocyclic three- to six-membered ring with the carbon to which it is attached, wherein each formed ring system optionally contains one or two oxygen atoms, and wherein each formed ring system is optionally substituted with one or two groups independently selected from alkyl and halo; R is (NRcRd)alkyl, which is attached to the parent molecular moiety through the alkyl part of the (NRcRd)alkyl, wherein the alkyl part of the (NRcRd)alkyl is a C1-C3 branched or straight chain group and wherein the alkyl part of the (NRcRd)alkyl is substituted with bicycloalkyl, fused bicycloheterocyclyl, cycloalkyl-substituted-heterocyclyl, ethenylcycloalkyl, heterocyclylethenyl, oxocycloalkyl, or spirocycloheterocyclyl, wherein the bicycloalkyl, bicycloheterocyclyl, oxocycloalkyl, and spirocycloheterocyclyl are optionally substituted with one or two groups independently selected from alkyl, halo, and haloalkyl; R′ is (NRcRd)alkyl, which is attached to the parent molecular moiety through the alkyl part of the (NRcRd)alkyl, wherein the alkyl part of the (NRcRd)alkyl is a C1-C3 branched or straight chain group and wherein the alkyl part of the (NRcRd)alkyl is optionally substituted with bicycloalkyl, fused bicycloheterocyclyl, cycloalkyl-substituted-heterocyclyl, ethenylcycloalkyl, heterocyclylethenyl, oxocycloalkyl, or spirocycloheterocyclyl, wherein the bicycloalkyl, bicycloheterocyclyl, oxocycloalkyl, and spirocycloheterocyclyl are optionally substituted with one or two groups independently selected from alkyl, halo, and haloalkyl; Ra and Rb are independently selected from hydrogen and alkyl; Rc and Rd are independently selected from hydrogen, alkenyloxycarbonyl, alkoxyalkylcarbonyl, alkoxycarbonyl, alkyl, alkylcarbonyl, aryl, arylalkoxycarbonyl, arylalkyl, arylalkylcarbonyl, arylcarbonyl, aryloxycarbonyl, cycloalkyl, cycloalkyloxycarbonyl, haloalkoxycarbonyl, heterocyclyl, heterocyclylalkoxycarbonyl, heterocyclylalkyl, heterocyclylalkylcarbonyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, (NReRf)carbonyl, Re and Rf are independently selected from hydrogen, alkyl, unsubstituted aryl, unsubstituted arylalkyl, unsubstituted cycloalkyl, unsubstituted (cyclolalkyl)alkyl, unsubstituted heterocyclyl, unsubstituted heterocyclylalkyl, (NRxRy)alkyl, and (NRxRy)carbonyl; and Rx and Ry are independently selected from hydrogen, alkoxycarbonyl, alkyl, alkylcarbonyl, unsubstituted aryl, unsubstituted arylalkoxycarbonyl, unsubstituted arylalkyl, unsubstituted cycloalkyl, unsubstituted heterocyclyl, and (NRx′Ry′)carbonyl, wherein Rx′ and Ry′ are independently selected from hydrogen and alkyl. |
