Cosmetic use of N-heteroarylbisamide analogs and related compounds

摘要

Cosmetic and dermatological compositions comprising N-heteroarylbisamide analogs and methods of using such compositions to impart anti-aging benefits to the skin and/or improve skin conditions resulting from reduced collagen and hyaluronic acid production are disclosed. The N-heteroarylbisamides are believed to stimulate collagen and hyaluronic acid production and restore or maintain homeostasis for these compounds.

主权项

1. A method for improving the aesthetic appearance of human skin comprising topically applying to an area of the skin in need thereof an amount of a cosmetic composition comprising a cosmetically acceptable vehicle and a dermatologically effective amount of a N-heteroarylbisamide of formula I:where:
Q is N or C; R, R2, R2, R3, R4 and R6 are independently H, C1-C8 alkyl, heteroalkyl, alkoxyalkyl, heteroalkoxyalkyl, C3-C8 cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyl-aryl, heteroalkyl-aryl, aryl-alkyl, and/or heteroaryl-alkyl; and R1 and R5 are independently H, C1-C8 alkyl, heteroalkyl, alkoxyalkyl, heteroalkoxyalkyl, C3-C8 cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyl-aryl, heteroalkyl-aryl, aryl-alkyl, and/or heteroaryl-alkyl or WR wherein W is CO, CO2, CONH, SO2, PO3, or CH(Oalkyl)2; and n is 3.