主权项 |
1. A polypeptide comprising an Fc region of a human IgGl antibody wherein said Fc region comprises a N297G mutation, using EU numbering scheme, one or more substitutions of the amino acid sequence set forth in SEQ ID NO: 3 at position V259, A287, R292, V302, L306, V323, or I332, using EU numbering scheme, with a cysteine amino acid residue, and said Fc region of a human IgGl comprises at least 95% identity to the amino acid sequence set forth in SEQ ID NO:3. |