| 发明名称 |
KINASE ACTIVITY DETECTION METHODS |
| 摘要 |
The invention provides cellular assays for detecting the activity of one or more kinase from multiple conditions simultaneously, by encoding biochemically identical substrates with isotope labels that enable them to be distinguished in pooled samples by mass spectrometry. |
| 申请公布号 |
US2017009273(A1) |
申请公布日期 |
2017.01.12 |
| 申请号 |
US201615207379 |
申请日期 |
2016.07.11 |
| 申请人 |
REGENTS OF THE UNIVERSITY OF MINNESOTA ;PURDUE RESEARCH FOUNDATION |
发明人 |
Parker Laurie L.;Yang Tzu-Yi;Davisson Vincent |
| 分类号 |
C12Q1/48 |
主分类号 |
C12Q1/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method comprising:
a) contacting a kinase with an isotope labeled substrate for the kinase; and b) detecting one or more reaction products from the activity of the kinase on the isotope labeled substrate for the kinase wherein the presence or quantity of one or more of the reaction products correlates with the activity of the kinase. |
| 地址 |
Minneapolis MN US |
