TRANSDERMAL DELIVERY METHOD FOR BIOACTIVE SUBSTANCE USING NANODIAMOND

摘要

The present invention relates to a method for delivering a bioactive substance into the skin by simultaneously attaching and solubilizing a hydrophilic bioactive substance and a hydrophobic bioactive substance on a surface of nanodiamond, followed by coating on a surface of the skin. The method of the present invention enables the solubilization of the hydrophobic bioactive substance and the loading of the hydrophobic bioactive substance together with the hydrophilic bioactive substance at the same time, so that the hydrophilic bioactive substance, which is difficult to penetrate into the skin stratum corneum, together with the hydrophobic substance, is delivered into the skin, thereby improving skin penetration. In the method of the present invention, the bioactive substance can be delivered into the skin without skin irritation or toxicity. In the method of the present invention, the skin penetration of the hydrophilic active substance, which is difficult to penetrate into the skin, can be improved by using a nanodiamond composite, and, at the same time, the nanodiamond per se remains on the surface of the skin to alleviate skin dryness through a moisturizing effect.