USE OF AMINE CARBOXYBORANES AS THERAPEUTIC DELIVERY OF CARBON MONOXIDE AND AS GENERAL DRUG DELIVERY SYSTEM IN THE PRESENCE OF REACTIVE OXYGEN SPECIES
摘要
Disclosed is a method of delivering therapeutic carbon monoxide to the cells and tissues of a patient which comprises administering thereto a compound of the formula XBY1Y2C(O)V (I) or pharmaceutically acceptable salts thereof. In addition, disclosed is a method of delivering a drug to a diseased cell or tissue by administering a compound of formula I either wherein at least one of X is a drug containing an amino group or V is a drug containing an amino group or hydroxyl group less a hydrogen on the amino or hydroxyl group. Further disclosed are novel compounds of Formula I.
申请公布号
WO2017007955(A1)
申请公布日期
2017.01.12
申请号
WO2016US41370
申请日期
2016.07.07
申请人
THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK;FLORIDA SOUTHWESTERN STATE COLLEGE;DINGRA, Nin N.;AYUDHYA, Theppawut Israsena Na