NOVEL PIPERIDINO-DIHYDROTHIENOPYRIMIDINE SULFOXIDES AND THEIR USE FOR TREATING COPD AND ASTHMA

摘要

Piperidino-dihydrothienopyrimidine sulfoxides of formula I;;wherein:
Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms andR is Cl and is located in the para-, meta-, or ortho-position of Ring A,S* is a sulphur atom that represents a chiral center,

and all pharmaceutically acceptable salts, enantiomers and racemates, hydrates and solvates thereof and the use of these compounds for the treatment of inflammatory or allergic diseases of the respiratory tract such as COPD or asthma.

主权项

1. A method of treating a disease which can be treated by the inhibition of the PDE4-enzyme comprising the step of administering to a patient in need thereof an effective amount of a compound of formula Iwherein:
Ring A is a 6-membered aromatic ring optionally comprising one or two nitrogen atoms, R is Cl and is located in the para-, meta-, or ortho-position of Ring A, and S* is a sulphur atom that represents a chiral center, or of a pharmaceutically acceptable salt thereof.