Statins of omega-3 polyunsaturated acids for treating hypercholesterolemia

摘要

The present invention relates to novel statin derivatives of omega-3 fatty acids, and their use in treating hypercholesterolemia, obesity, hypertriglyceridemia, cardiovascular diseases, and metabolic diseases, and Alzheimer's disease.

主权项

1. A compound of Formula (I) or Formula (II) having the formula: wherein:
R is joined from the aldehyde group formed by the partial reduction of the carboxylic acid of: cis,cis,cis-7,10,13-hexadecatrienoic acid (HTA) of the following structure: cis,cis,cis-9,12,15-octadecatrienoic acid (ALA) of the following structure: cis,cis,cis,cis-6,9,12,15-octadecatetraenoic acid (SDA) of the following structure: cis,cis,cis-11,14,17-eicosatrienoic acid (ETE) of the following structure: cis,cis,cis,cis-8,11,14,17-eicosatetraenoic acid (ETA), of the following structure: cis,cis,cis,cis-5,8,11,4,17-eicosapentanenoic acid (EPA) of the following structure: cis,cis,cis,cis,cis-6,9,12,15,18-heneicosapentaenoic acid (HPA) of the following structure: cis,cis,cis,cis,cis-7,10,13,16,19-docosapentaenoic acid (DPA) of the following structure: cis,cis,cis,cis,cis-4,7,10,13,16,19-docosahexaenoic acid (DHA) of the following structure: cis,cis,cis,cis-9,12,15,18,21-tetracosapentaeonic acid (TPA) of the following structure: or cis,cis,cis,cis,cis,cis-6,9,12,15,18,21-tetracosahexaeonic acid (THA) of the following structure: or the pharmaceutically-acceptable salts of Formula (II).