NUCLEOSIDE PHOSPHORAMIDATES

摘要

Disclosed herein are nucleoside phosphoramidates and their use as an agents for treating viral diseases. More particularly, it is disclosed the phosphorus-based diastereomers (see formula I) or crystalline (S)-isopropyl 2-(((S)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate represented by the formula (see formula II) These compounds are inhibitors of RNA-dependent RNA viral replication and are useful as inhibitors of HCV NS5B polymerase, as inhibitors of HCV replication and for treatment of hepatitis C infection in mammals.