Use of cytokine-releasing, biodegradable particles in hyaluronic acid for the treatment of cartilage defects, in particular of osteoarthrosis

摘要

The present invention relates to a composition comprising, or consisting of 2-50 mg/ml hyaluronic acid, 0.1-500 mg/ml of biodegradable particles with an average mean particle diameter of 1 nm-500 μm, 1 pg/ml-10 μg/ml cytokines, where the concentrations specified are based in each case on the total volume (w/v) of the composition and where the cytokines are enclosed in the biodegradable particles, and to their use in the treatment of cartilage defects, for example traumatic cartilage defects or osteoarthrosis.

主权项

1. A composition comprising:  2-50 mg/mlhyaluronic acid;0.1-500 mg/mlbiodegradable particles with an average mean particlediameter of 1 nm-500 μm;1 pg/ml-10 μg/mlCCL25 cytokine; wherein the details of the concentration in each case relate to the total volume (w/v) of the composition and wherein the CCL25 cytokine is enclosed in the biodegradable particles and the combination of hyaluronic acid and CCL25 cytokines synergistically promotes the migration of mesenchymal stem or progenitor cells.