| 发明名称 |
Formulation, apparatus and method for stabilizing radiopharmaceuticals |
| 摘要 |
A formulation for stabilizing a radiopharmaceutical. The formulation includes a radiopharmaceutical (or a pharmaceutically acceptable salt thereof), a gas which has oxygen, a stabilizer, and a solvent. |
| 申请公布号 |
US9539349(B2) |
申请公布日期 |
2017.01.10 |
| 申请号 |
US201615133623 |
申请日期 |
2016.04.20 |
| 申请人 |
Siemens Medical Solutions USA, Inc. |
发明人 |
Kolb Hartmuth C.;Walsh Joseph C.;Mocharla Vani P.;Mu Fanrong;Gangadharmath Umesh |
| 分类号 |
A61K51/12;A61K9/00;A61K51/04;A61K47/02;A61K47/12;A61J1/06;B65D81/20 |
主分类号 |
A61K51/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of making a formulation for stabilizing a radiopharmaceutical, the method comprising:
providing a F18 labelled radiopharmaceutical, or a pharmaceutically acceptable salt of a F-18 labelled radiopharmaceutical thereof in a vial; providing an aqueous solution of an alcohol and an inorganic salt in the vial; providing a gas comprising oxygen in the vial; wherein the oxygen is present in the gas in an amount of at least about 10 vol. % by total volume of gas; providing an excipient in the vial, wherein the excipient is maleic acid. |
| 地址 |
Malvern PA US |
