| 发明名称 |
Pyrrolopyrimidines as therapeutic agents for the treatment of diseases |
| 摘要 |
Compounds of formula (I) and salts thereof:;
wherein R1 is n-C4-6alkyl or C1-2alkoxyC1-2alkyl-; R2 is hydrogen or methyl; each R3 is hydroxy, halo or n-C1-3alkyl; m is an integer having a value of 2 to 4; n is an integer having a value of 0 to 3; and p is an integer having a value of 0 to 2, are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions, for example allergic rhinitis and asthma, infectious diseases and cancer, and may also be useful as vaccine adjuvants. |
| 申请公布号 |
US9540383(B2) |
申请公布日期 |
2017.01.10 |
| 申请号 |
US201314443932 |
申请日期 |
2013.11.18 |
| 申请人 |
GlaxoSmithKline LLC |
发明人 |
Coe Diane Mary;Smith Stephen Allan |
| 分类号 |
A61K31/519;C07D487/04;A61K39/00 |
主分类号 |
A61K31/519 |
| 代理机构 |
|
代理人 |
Octavio Leah M.;Lockenour Andrea V. |
| 主权项 |
1. A compound of formula (I), or a pharmaceutically acceptable salt thereof:wherein:
R1 is n-C4-6alkyl or C1-2alkoxyC1-2alkyl-; R2 is hydrogen or methyl; each R3 is hydroxy, halo or n-C1-3alkyl; m is an integer having a value of 2 to 4; n is an integer having a value of 0 to 3; p is an integer having a value of 0 to 2. |
| 地址 |
Wilmington DE US |
