| 发明名称 |
USE OF VHH ANTIBODIES FOR THE PREPARATION OF PEPTIDE VECTORS FOR DELIVERING A SUBSTANCE OF INTEREST AND THEIR APPLICATIONS |
| 摘要 |
Use of a variable fragment (VHH antibody) of a camelid single-chain antibody for the preparation of a peptide vector for delivering a substance of interest across the blood-brain barrier or into a cell. |
| 申请公布号 |
US2017002065(A1) |
申请公布日期 |
2017.01.05 |
| 申请号 |
US201615176641 |
申请日期 |
2016.06.08 |
| 申请人 |
INSTITUT PASTEUR ;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
发明人 |
ROUGEON Francois;Lafaye Pierre;Bourgeois Jean-Pierre |
| 分类号 |
C07K16/18;A61K47/48 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of preparing a peptide vector, comprising linking a variable fragment (VHH antibody) of a camelid single-chain antibody having an isoelectric point of at least 8.5 to a substance of interest suitable to be delivered across a mammalian blood-brain barrier, wherein brain transendothelial migration of said VHH antibody being inhibited in the presence of amiloride in vitro. |
| 地址 |
Paris FR |
