| 主权项 |
1. A compound selected from a compound of Formula I:and pharmaceutically acceptable salts thereof, wherein in Formula I:
R1 is C1-8 alkyl, C1-8 haloalkyl, C1-8 alkoxy, C3-12 cycloalkyl, C-linked C2-11 heterocycloalkyl, heteroaryl, or —NR1AR1B, wherein R1A and R1B are each independently selected from the group consisting of hydrogen, C1-8 alkyl, C1-8 alkoxy, (6-10 membered aryl)-(XR1)0-1—, (5-10 membered heteroaryl)-(XR1)0-1—, and wherein R1A and R1B are optionally combined to form a 3 to 9 membered heterocyclic ring optionally comprising 1 additional heteroatom selected from N, O and S and optionally fused thereto is a benzene or pyridine ring; XR1 is selected from the group consisting of C1-4 alkylene, C1-4 heteroalkylene, C2-4 alkenylene, C2-4 alkynylene; and wherein the aliphatic and aromatic portions of R1 are optionally substituted with from 1 to 5 RR1 substituents selected from the group consisting of C1-8 alkyl, C1-8 haloalkyl, F, Cl, Br, I, —OH, —CN, —NO2, ═O, —(X1R)0-1NRR1aRR1b, —(X1R)0-1ORR1a, —(X1R)0-1SRR1a, —(X1R)0-1N(RR1a)C(═O)ORR1c, —(X1R)0-1OC(═O)N(RR1a)(RR1b), —(X1R)0-1N(RR1a)C(═O)N(RR1a)(RR1b), —(X1R)0-1C(═O)N(RR1a)(RRb), —(X1R)0-1N(RR1a)C(═)RR1b, —(X1R)0-1C(═O)ORR1a, —(X1R)0-1OC(═O)RR1a, —(X1R)0-1—P(═O)(ORR1a)(ORR1b), —(X1R)0-1S(O)1-2RR1c, —(X1R)0-1S(O)1-2N(RR1a)(RR1b), —(X1R)0-1N(RR1a)S(O)1-2N(RR1a)(RR1b) and —(X1R)0-1N(RR1a)S(O)1-2(RR1c), wherein X1R is selected from the group consisting of C1-4 alkylene, C1-4 heteroalkylene, C2-4 alkenylene and C2-4 alkynylene; wherein RR1a and RRib are independently selected from the group consisting of hydrogen, C1-8 alkyl, C1-8 haloalkyl, C3-8 cycloalkyl, phenyl, benzyl, heteroaryl, and C2-7 heterocycloalkyl; RR1c is selected from the group consisting of C1-8 alkyl, C1-8 haloalkyl, C3-8 cycloalkyl, phenyl, benzyl, heteroaryl, and C2-7 heterocycloalkyl; RN is hydrogen, C1-4 alkyl or C1-4 haloalkyl; B is C or N; R2, R3 and R4 are each independently selected from the group consisting of H, F, Cl, Br, I, —CN, C1-8 alkyl, C1-8 haloalkyl and C1-8 alkoxy, and R3 is absent when B is nitrogen; R5 is selected from the group consisting of H, F, Cl, Br, I, —CN, C1-8 alkyl, C2-8 alkenyl, C1-8 haloalkyl, C1-8 alkoxy, C3-8 cycloalkyl, C2-7 heterocycloalkyl, phenyl and 5-6 membered heteroaryl comprising 1 to 3 heteroatoms selected from N, O and S, wherein said 5-6 membered heteroaryl, C1-8 alkyl, C3-8 cycloalkyl or C2-7 heterocycloalkyl is further optionally substituted with from 1 to 3 R5a substituents selected from F, Cl, Br, I, —OH, ═O, C3-6 cycloalkyl, —CN, C1-4 alkyl, —C1-4 alkyl-O—C1-4 alkyl, C1-4 haloalkyl and C1-4 alkoxy; L is a linker selected from the group consisting of C1-4 alkylene, C2-4 alkenylene, C2-4 alkynylene, and C1-4 heteroalkylene, wherein L is optionally substituted with from 1 to 3 RL substituents selected from the group consisting of ═O, —OH, —OCH2.phenyl, C1-4 alkyl, C1-4 haloalkyl and C1-4 acyl; the subscript m represents the integer 0 or 1; X1 and X2 are each independently selected from the group consisting of absent, —O—, —S(O)—, —S(O)2— and —N(RX)— wherein RX is H, C1-8 alkyl, C1-8 acyl or —S(O)2(C1-8 alkyl), and wherein if the subscript m is 0 then at least one of X1 or X2 is absent; the subscript n is an integer from 0 to 5; A is selected from the group consisting of hydrogen, C3-12 cycloalkyl, C2-11 heterocycloalkyl, phenyl having a 3-8 membered carbocyclic or heterocyclic ring comprising 1 to 3 heteroatoms selected from N, O and S fused thereto or a 5 to 6 membered heteroaryl having a 3-8 membered carbocyclic or heterocyclic ring comprising 1 to 3 heteroatoms selected from N, O and S fused thereto, and wherein if A is hydrogen then the subscript n is 0; and RA is selected from the group consisting of C1-8 alkyl, C3-8 cycloalkyl, C1-8 haloalkyl, F, Cl, Br, I, —OH, —CN, —NO2, ═O, heteroaryl, —(XRA)0-1NRA1RA2, —(XRA)0-1ORA1, —(XRA)0-1SRA1, —(XRA)0-1N(RA1)C(═O)ORA3, —(XRA)0-1OC(═O)N(RA1)(RA2), —(XRA)0-1N(RA1)C(═O)N(RA1)(RA2), —(XRA)0-1C(═O)N(RA1)(RA2), —(XRA)0-1N(RA1)C(═O)RA2, —(XRA)0-1C(═O)ORA1, —(XRA)0-1OC(═O)RA1, —P(═O)(ORA1)(ORA2), —(XRA)0-1S(O)1-2RA3, —(XRA)0-1S(O)1-2N(RA1)(RA2), —(XRA)0-1N(RA1)S(O)1-2N(RA1)(RA2) and —(XRA)0-1N(RA1)S(O)1-2(RA3), wherein XRA is selected from the group consisting of C1-4 alkylene, C1-4 heteroalkylene, C2-4 alkenylene and C2-4 alkynylene; wherein RA1 and RA2 are independently selected from the group consisting of hydrogen, C1-8 alkyl, C2-8 alkenyl, C1-8 haloalkyl, C3-8 cycloalkyl, tetrahydronapthalene, phenyl, benzyl, heteroaryl, and C2-7 heterocycloalkyl; RA3 is selected from the group consisting of C1-8 alkyl, C1-8 haloalkyl, C3-8 cycloalkyl, tetrahydronapthalene, phenyl, benzyl, heteroaryl, and C2-7 heterocycloalkyl; wherein if A is a monocyclic C3-12 carbocycloalkyl or monocyclic C2-11 heterocycloalkyl, then any two RA substituents attached to adjacent atoms on the A ring are optionally combined to form a benzene or a 5 to 6 membered heteroaryl ring; and wherein the aliphatic and aromatic portions of a RA substitutent is optionally substituted with from 1 to 5 RR1 substitutents selected from, F, Cl, Br, I, —NH2, —OH, —CN, —NO2, ═O, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4(halo)alkyl-C(═O)—, C1-4 (halo)alkyl-S(O)0-2—, C1-4(halo)alkyl-C(═O)N(H)—, C1-4 (halo)alkyl-N(H)—C(═O)—, ((halo)alkyl)2N—C(═O)—, C1-4(halo)alkyl-OC(═O)N(H)—, C1-4(halo)alkyl-OC(═O)N(H)—, (halo)alkyl-N(H)—C(═O)O—, ((halo)alkyl)2N—C(═O)O—, C1-4 alkylamino, C1-4 dialkylamino, C3-6 cycloalkyl, C3-6 cycloalkoxy, C2-5 heterocycloalkoxy, tetrahydronaphthalene and phenyl wherein phenyl is optionally substituted with 1-3 fluoro, chloro, bromo, CN, C1-6 alkyl, C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkoxy, C1-6 alkylamino, or C1-6dialkylamino; with the proviso that a compound of Formula I is not 4-(cyclohexylmethoxy)-N-(methylsulfonyl)benzamide; 4-(cyclopentylmethoxy)-N-(methylsulfonyl)benzamide or 4-(cyclobutylmethoxy)-2,5-difluoro-N-(methylsulfonyl)benzamide. |
