发明名称 |
METHOD FOR PRODUCING 1,4-BENZOXAZINE COMPOUND |
摘要 |
The present invention provides an industrially advantageous method for producing a 1,4-benzoxazine compound useful as a medicine while avoiding safety and health risks. Specifically, the present invention provides a method for producing a 1,4-benzoxazine compound [A], which comprises the three steps in the following scheme, namely, a step of converting the amino group at 7-position in a compound [a] into a dimesylamino group, a step of coupling a compound [b] with a boronic acid compound, and a step of converting the 7-position in a compound [c] into a monomesylamino group. In the above scheme, Ms is a methanesulfonyl group, and each of R' and R" is a hydrogen atom etc. |
申请公布号 |
EP3112354(A1) |
申请公布日期 |
2017.01.04 |
申请号 |
EP20160178154 |
申请日期 |
2013.08.08 |
申请人 |
Mitsubishi Tanabe Pharma Corporation |
发明人 |
Okabe, Tomoyuki;Hamada, Takeshi;Tomikawa, Kaori;Okamoto, Yukie;Iijima, Toru;Akatsuka, Hidenori;Toyama, Kenichi;Moroda, Atsushi;Sugiura, Yoshihiro |
分类号 |
C07D265/36;A61K31/538;A61P9/00 |
主分类号 |
C07D265/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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