发明名称 |
BREAST CANCER CELL GROWTH-INHIBITING ENZYME INHIBITORS, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF |
摘要 |
Novel enzyme inhibitors for treatment of breast cancer combine the inhibition of enzymes that combat aggressive breast cell growth both synergistically and additively. Pyrido-annulated indoles developed act in a selectively inhibiting manner on the enzymes HER2 and/or Brk in the nanomolar to picomolar concentration range in screening more than 200 kinases of the human kinome. The enzyme inhibitors inhibit the growth of breast cancer cells in the nanomolar concentration range without exhibiting critical toxic effects. The derivatization at the 6-position of the 4-chloro-α-carboline is achieved without by-products and, similarly to the derivatization at the 4-position with the aniline derivatives, takes place at high purity with quantitative yields. |
申请公布号 |
EP3110421(A2) |
申请公布日期 |
2017.01.04 |
申请号 |
EP20140799883 |
申请日期 |
2014.08.21 |
申请人 |
Martin-Luther-Universität Halle-Wittenberg |
发明人 |
HILGEROTH, Andreas |
分类号 |
A61K31/437;A61K31/4375;A61P35/00 |
主分类号 |
A61K31/437 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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