| 发明名称 | Surface preparation method | ||
| 摘要 | A method of covalently immobilizing a charged chemical species on or near a sensor surface of a mass-sensitive chemical sensor, the sensor surface bearing functional groups capable of forming covalent bonds with the chemical species, the method involving the application of an electric field between the charged chemical species and the sensor surface such that the electrostatic attraction therebetween is increased. | ||
| 申请公布号 | US9533881(B2) | 申请公布日期 | 2017.01.03 |
| 申请号 | US200511666194 | 申请日期 | 2005.10.21 |
| 申请人 | Attana AB | 发明人 | Aastrup Teodor;Wallinder Daniel;Anderson Henrik |
| 分类号 | C12Q1/00;B82Y30/00;B82Y15/00;C12Q1/68;G01N29/02;G01N33/543 | 主分类号 | C12Q1/00 |
| 代理机构 | Banner & Witcoff, Ltd. | 代理人 | Banner & Witcoff, Ltd. |
| 主权项 | 1. A method of covalently immobilising a charged chemical species, comprising providing a sensor surface for a chemical sensor, wherein the sensor surface bears a net negative charge and comprises functional groups capable of forming covalent bonds with the charged chemical species, applying an electric field between the charged chemical species and the sensor surface, wherein an electrostatic repulsion between the charged species and the sensor surface is reduced, and covalently immobilizing the charged chemical species on the sensor surface, wherein the sensor surface bears a plurality of carboxyl groups, and further wherein the charged chemical species is a polypeptide that has a net negative charge during the immobilisation. | ||
| 地址 | Stockholm SE | ||