| 发明名称 |
Polypeptide compounds for inhibiting angiogenesis and tumor growth |
| 摘要 |
In certain embodiments, this present invention provides polypeptide compositions, including compositions containing a modified polypeptide, and methods for inhibiting Ephrin B2 or EphB4 activity. In other embodiments, the present invention provides methods and compositions for treating cancer or for treating angiogenesis-associated diseases. |
| 申请公布号 |
US9533026(B2) |
申请公布日期 |
2017.01.03 |
| 申请号 |
US201313887819 |
申请日期 |
2013.05.06 |
| 申请人 |
VASGENE THERAPEUTICS, INC |
发明人 |
Krasnoperov Valery;Kertesz Nathalie;Reddy Ramachandra;Gill Parkash;Zozulya Sergey |
| 分类号 |
A61K38/00;A61K39/00;A61K38/38;A61K47/48;C07K14/715 |
主分类号 |
A61K38/00 |
| 代理机构 |
|
代理人 |
Crandall Craig A |
| 主权项 |
1. An isolated fusion polypeptide consisting of a sequence selected from the group consisting of: residues 16-197, 16-321, 16-326, 16-427, 16-429, and 16-526 of SEQ ID NO: 10; and (b) an albumin protein or fragment thereof, wherein the fusion polypeptide is a monomer, binds specifically to an Ephrin B2 polypeptide, and inhibits signaling that results from interaction between EphB4 and Ephrin B2. |
| 地址 |
Los Angeles CA US |
