Vaginal ring including meloxicam and an agent for modulating the release of the active principle, which can be used as a continuous-use contraceptive in women

摘要

The invention relates to a sustained-release vaginal ring which includes meloxicam and an agent for modulating the release of the active principle, such as polyvinylpyrrolidone K-30, which releases the active principle over at least 90 days and which can be used as a continuous-use contraceptive in women. The vaginal ring preferably includes 5 wt % to 30 wt % of meloxicam, relation to total weight of the formulation.

主权项

1. A sustained-release vaginal ring comprising a homogenous mixture of meloxicam, two polymers and polyvinylpyrrolidone K-30 as a release enhancing agent for sustained release of the active ingredient meloxicam, wherein the two polymers are a mixture of polymer A and polymer B and wherein the polymer A is polydimethylsiloxane-vinyl block polymer, amorphous silica and platinum catalyst, and polymer B is dimethyl methyl hydrogen siloxane copolymer and polydimethylsiloxane.