| 发明名称 |
OPTIMIZED FC VARIANTS AND METHODS FOR THEIR GENERATION |
| 摘要 |
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants, in particular a variant polypeptide comprising an Fc variant of a parent Fc polypeptide, said Fc variant comprising the amino acid substitution P238D as compared to said parent Fc polypeptide, wherein said numbering is according to the EU index. |
| 申请公布号 |
EP3101030(A1) |
申请公布日期 |
2016.12.07 |
| 申请号 |
EP20160180152 |
申请日期 |
2004.03.26 |
| 申请人 |
Xencor, Inc. |
发明人 |
LAZAR, Gregory Alan;CHIRINO, Arthur J.;DANG, Wei;DESJARLAIS, John Rudolph;DOBERSTEIN, Stephen Kohl;HAYES, Robert J.;KARKI, Sher Bahadur;VAFA, Omid |
| 分类号 |
C07K16/00;C07K16/24;C07K16/28;C07K16/30;C07K16/32 |
主分类号 |
C07K16/00 |
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