摘要 |
The invention provides compositions comprising Eno1 for delivery to a muscle. Further, the invention provides a method for normalizing blood glucose in a subject with elevated blood glucose, comprising administering to the subject enolase 1 (Eno1), thereby normalizing blood glucose in the subject. The invention also provides methods of treating one or more conditions including impaired glucose tolerance, insulin resistance, pre-diabetes, and diabetes, especially type 2 diabetes in a subject, comprising administering to the subject enolase 1 (Eno1), thereby treating the condition in the subject. In certain methods of the invention, the Eno1 is delivered to muscle. |
申请人 |
BERG LLC;UNIVERSITY OF MIAMI |
发明人 |
NARAIN, NIVEN, RAJIN;SARANGARAJAN, RANGAPRASAD;VISHNUDAS, VIVEK, K.;GESTA, STEPHANE;JING, ENXUAN;DAUNERT, SYLVIA;DEO, SAPNA, K.;JIMENEZ, JOAQUIN, JUAN;DIKICI, EMRE;DAFTARIAN, PIROUZ, MOHAMMAD |