发明名称 |
STEM CELL-DERIVED HEPATOCYTES IN CO-CULTURE AND USES THEREOF |
摘要 |
The present disclosure provides co-cultures of human pluripotent stem cell derived hepatocytes and at least one non-parenchymal cell population in vitro, methods of preparing the co-cultures and methods of using the co-cultures for high throughput screening and evaluation of drug candidates. The stem cell derived hepatocyte co-culture system provides an in vitro model in which cell viability and relatively mature hepatocyte phenotype of stem cell derived hepatocytes are maintained for extended periods relative to conventional monoculture. |
申请公布号 |
EP3094719(A2) |
申请公布日期 |
2016.11.23 |
申请号 |
EP20150737664 |
申请日期 |
2015.01.14 |
申请人 |
COLORADO STATE UNIVERSITY RESEARCH FOUNDATION |
发明人 |
KHETANI, Salman R.;BERGER, Dustin R.;WARE, Brenton R. |
分类号 |
C12N5/07 |
主分类号 |
C12N5/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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