Disclosed herein are methods and compositions for targeted integration of one or more copies of a sequence of interest using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain and integrase defective lentiviral donor constructs.
申请公布号
EP2597155(B1)
申请公布日期
2016.11.23
申请号
EP20130156104
申请日期
2008.10.23
申请人
SANGAMO BIOSCIENCES, INC.;OSPEDALE SAN RAFFAELE S.R.L.
发明人
HOLMES, MICHAEL C.;YAO, SHUYUAN;NALDINI, LUIGI;LOMBARDO, ANGELO LEONE