IN VITRO ASSESSMENT OF CARDIOVASCULAR EVENTS BY ASSAY FOR NEO-EPITOPES OF TITIN PROTEIN

摘要

A bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a titin protein by a proteinase comprises contacting a sample with an antibody specifically binding said neo-epitope and determining the level of binding. Partial sequences of titin that may be detected include: 13519′↓GEYVCDCGTD ′13528 13532′ NVTVEARLIK↓′13542 13543′↓VEKPLYGVEV ′1553