发明名称 |
PEPTIDES HAVING REDUCED TOXICITY THAT STIMULATE CHOLESTEROL EFFLUX |
摘要 |
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABCA1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation. |
申请公布号 |
EP2983687(A4) |
申请公布日期 |
2016.11.16 |
申请号 |
EP20140763923 |
申请日期 |
2014.03.14 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
BIELICKI, JOHN K.;JOHANSSON, JAN;DANHO, WALEED |
分类号 |
A61K38/00;A61K38/17;A61K45/06;A61K47/48;C07K14/435;C07K14/775 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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