发明名称 |
FUSION PROTEIN HAVING DUAL-FUNCTIONS FOR INHIBITING ANGIOGENESIS IN TUMOUR MICROENVIRONMENT AND ACTIVATING ADAPTIVE IMMUNE RESPONSE AND GENE AND USE THEREOF |
摘要 |
Disclosed are bifunctional fusion proteins having Tumstatin active fragments and CD137L extracellular regions. The proteins exhibit activities to inhibit the proliferation of human umbilical vein endothelial cells and to costimulate the proliferation of T cells. They can be used for the treatment of various tumor-related diseases and the regulation of angiogenesis and immunological effects in humans. |
申请公布号 |
EP2995626(A4) |
申请公布日期 |
2016.11.09 |
申请号 |
EP20140795356 |
申请日期 |
2014.05.05 |
申请人 |
CHINA PHARMACEUTICAL UNIVERSITY |
发明人 |
WANG, SHUZHEN;CHEN, YIJUN;HE, DONGYANG;LIU, NAN;MA, CHAO;GAO, ZHENYUE |
分类号 |
C07K19/00;A61K38/00;A61K38/17;A61P9/00;A61P35/00;A61P37/02;C07K14/705;C07K14/78;C12N15/62;C12N15/63 |
主分类号 |
C07K19/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|