IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE

摘要

The invention provides immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.

主权项

1. A method for therapeutically treating a mammal having an inflammatory disorder mediated by TLR9, TLR7, and/or TLR8, comprising administering to the mammal an immune regulatory oligonucleotide (IRO) selected from 5′-C*TATC*TGUC*G1TTC*TC*TGU-3′ and 5′-CTATCTGUC*G2TTCTCTGU-3′, wherein G1=7-deaza-dG; C*=5-Me-dC; G=2′-O-Me-G; U=2′-O-Me-U; and G2=AraG or a composition thereof.