BENZAMIDE DERIVATIVES

摘要

Benzamide derivatives of the following formula (I): (I) ¢wherein R1: B, D: hydrogen atom, etc. E: pyridyl group, etc. n: integer from 0 to 2 R2: R3R4N- etc. (R3, R4: optionally substituted C6 - C12 aryl group, etc.) A: -?- ,-CH2-, -N=N-, -CH=N-, -N=CH-, CH=CH- or -CH2-CH2-!. optical antipodes thereof or pharmaceutically acceptable salts thereof, show excellent PAF antagonism and are effective for therapy and prophylaxis of diseases caused by PAF (bronchial asthma, nephritis, shocks, cardiac infarction, cerebral hemorrhage, ulcer, DIC, autoimmune diseases, thrombosis, etc.).