NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST THE NOGO-66 RECEPTOR (NGR) AND USES THEREOF
摘要
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 receptor. These antibodies or portions thereof of the invention are useful for detecting NgR and for inhibiting NgR activity, for example in a human suffering from a disorder in which NgR or Nogo-66 activity is detrimental.
申请公布号
EP2091563(B1)
申请公布日期
2016.10.26
申请号
EP20070854735
申请日期
2007.11.21
申请人
ABBOTT LABORATORIES
发明人
MEZLER, MARIO;MOELLER, ACHIM;MUELLER, REINHOLD;MUELLER, BERNHARD K.;GHAYUR, TARIQ;BARLOW, EVE H.;SCHMIDT, MARTIN;MEYER, AXEL;TEUSCH, NICOLE