发明名称 |
PROCESS FOR THE PREPARATION OF COLESEVELAM |
摘要 |
The present invention relates to a new process for the synthesis of Colesevelam, which is used in therapy in cases of hypercholesterolemia due to low density lipoproteins. Said process comprises the reaction, in a basic environment, of polyallylamine with: i) at least one alkylating agent of formula X—(CH2)9—CH3 and at least one alkylating agent of formula Y—(CH2)6—N+ (CH3)3Z−, wherein X and Y are each independently a leaving group, and Z is a halogen; and ii) at least one crosslinking agent. The present invention also relates to the Colesevelam obtainable by the above process. |
申请公布号 |
EP3083712(A1) |
申请公布日期 |
2016.10.26 |
申请号 |
EP20140830666 |
申请日期 |
2014.12.16 |
申请人 |
CHEMI S.P.A. |
发明人 |
GABOARDI, MAURO;BARUTO, ALESSANDRO;CASTALDI, MARTA |
分类号 |
C08F8/00;C08F8/02;C08F8/30;C08F8/44;C08F226/02 |
主分类号 |
C08F8/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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