| 摘要 |
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like. |
| 主权项 |
1. A compound having the structure of Formula (III), or a pharmaceutically acceptable salt thereof, wherein,X and Y are each independently chosen from C—H, C—F, C—CH3, or N;Z is chosen -G, —CH2-G, —CH2—CH2-G, —N(R1)-G, —N(R1)—CH2-G, —O-G, —O—CH2-G, or —C(O)N(R2)(R3);G is carbocyclyl, aryl, heterocyclyl or heteroaryl;R1 is hydrogen or alkyl;R2 and R3 are independently selected from hydrogen, alkyl, heterocyclyl, heterocyclylalkyl, or optionally, R2 and R3 join to form an N-linked heterocyclyl ring system;R is chosen from alkoxy, carbocyclylalkyloxy, carbocyclyl, carbocyclylalkyl, aryl, aralkyl, heteroaryl, heterocyclyl, alkynyl, carbocyclylalkynyl, heterocyclylalkynyl, or heteroarylalkynyl; andR4 is hydrogen, halogen, C1-C3 alkyl, C1-C3 alkoxy, or —N(R2)(R3). |
