发明名称 |
EPIDERMAL GROWTH FACTOR RECEPTOR VARIANT III-MESOTHELIN FUSIONS AND METHODS OF USING THE SAME |
摘要 |
Provided herein are compositions and methods for eliciting an immune response in a subject. In particular, the present disclosure is directed to fusion proteins comprising an epidermal growth factor receptor variant III (EGFRvIII) polypeptide and a mesothelin polypeptide, and methods of eliciting an immune response using host cells comprising nucleic acid molecules encoding said fusion proteins. In some embodiments, the nucleic acid molecules can encode an EGFRvIII-mesothelin fusion protein comprising an amino acid sequence that is at least i) 90% identical, ii) 95% identical, or iii) 99% identical to EGFRvIIIx5-mesothelin35-622 as set forth in SEQ ID NO:8. |
申请公布号 |
WO2016168198(A1) |
申请公布日期 |
2016.10.20 |
申请号 |
WO2016US27136 |
申请日期 |
2016.04.12 |
申请人 |
ADURO BIOTECH, INC. |
发明人 |
LAUER, Peter, M.;HANSON, William, G. |
分类号 |
C07K14/735;A61K39/00;C12N15/62 |
主分类号 |
C07K14/735 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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