发明名称 |
ANTIGEN-BINDING MOLECULES, THE ANTIGEN-BINDING ACTIVITY OF WHICH VARIES ACCORDING TO THE CONCENTRATION OF COMPOUNDS, AND LIBRARIES OF SAID MOLECULES |
摘要 |
An objective of the present invention is to provide target tissue-specific antigen-binding molecules, antigen-binding molecules whose antigen-binding activity varies depending on the concentration of an unnatural compound, libraries comprising a plurality of the antigen-binding molecules which are different from one another, pharmaceutical compositions comprising the antigen-binding molecules, methods of screening for the antigen-binding molecules, and methods for producing the antigen-binding molecules. The present inventors created antigen-binding domains whose antigen-binding activity varies depending on the concentration of a small molecule compound or antigen-binding molecules containing an antigen-binding domain, and libraries comprising a plurality of the antigen-binding domains which are different from one another or antigen-binding domains, and demonstrated that the above-noted objective could be achieved by using the libraries. Various diseases originating from target tissues can be treated in a target tissue-specific manner by using the antigen-binding molecules of the present invention. |
申请公布号 |
EP3078744(A1) |
申请公布日期 |
2016.10.12 |
申请号 |
EP20140867380 |
申请日期 |
2014.12.04 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IGAWA, TOMOYUKI;TAMBA, SHIGERO;SHIMIZU, SHUN;TATSUMI, KANAKO;KADONO, SHOJIRO;KAWAUCHI, HIROKI;OHARA, KAZUHIRO;MATSUSHITA, MASAYUKI;EMURA, TAKASHI;KAMIMURA, MASAKI |
分类号 |
C12N15/09;A61K39/00;C07K16/00;C07K19/00;C12P21/08;C40B40/08;C40B40/10 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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