Process for the crystallisation of cefadroxil monohydrate

摘要

The present invention relates to a process for the preparation of cefadroxil in crystal form, comprising:
a) adding an aqueous solution of cefadroxil to a crystallisation vessel and a titrant to keep a pH in the crystallisation vessel of between 7 to 9; and
b) lowering the pH in the crystallisation vessel to a value of between 5 and 6.5 to obtain a suspension of the ²-lactam compound in crystal form.